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Mechanism of action of opioids

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Mechanism of action of opioids

Opioid agonists produce analgesia by binding to G protein-coupled receptors (GPCRs) in the brain and spinal cord regions involved in the transmission and modulation of pain Opioid drugs mimic endogenous compounds: endorphins, enkephalins, and dynorphins that bind to opioid receptors. Four opioid receptor types: mu (μ), kappa (κ), delta (δ ...

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What causes opioid addiction, and why is it so tough to combat? - Mike Davis

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Central analgesic pathways affected by opioids

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