Sep 6, 2010 · An increase in mortality when tranexamic acid was given instead of aprotinin is also a conclusion from the current article [1]. Neurological outcomes is a long standing safety concern as …

Jul 1, 2019 · To ex-plore the mechanism of action of tranexamic acid in TBI patients, we examined the timing of its effect on death. We also set the results of our analysis in the context of other trials of …

Introduction: To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality. We hypothesised that if TXA reduces …

Tranexamic acid used in the perioperative setting safely reduces transfusion requirements in children. This article compares the hematologic response to trauma between children and adults, and …

Background: Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth. However, its efects on thrombotic events and seizures are less clear. We …

Mar 20, 2012 · We performed a randomized, double-blind study in 37 patients who underwent cesarean section. Patients were divided into two groups: the first group (n = 19) received preoperative (30 …

Mar 21, 2006 · CPB results in fibrinolysis as reflected by increased plasmin concentrations and fibrin degradation products, both of which have deleterious effects on platelet function. We designed a …

Mar 1, 2010 · After approval by the ethics committee, we randomly assigned women with PPH >800 ml after vaginal delivery to receive intravenous tranexamic acid (TXA) (4 g within 1 hour, followed by 1 …

Mar 1, 2011 · Although tranexamic acid (TA) has been effective in reducing bleeding after cardiac surgery, the TA dosing scheme varies extremely and the agent is highly overdosed in most relevant …

Survival has been considered the cornerstone for clinical outcome evaluation in critically ill patients admitted to intensive care unit (ICU). There is evidence that ICU survivors commonly show …