San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is off the injury report and ready to roll for a ...

The final injury report for both the Arizona Cardinals and San Francisco 49ers just dropped, and the two sides could be ...

San Francisco 49ers head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, TE George Kittle and others before the team's Week 18 matchup against the Cardinals and shared his vision ...

There are numerous player prop betting options on Isaac Guerendo for the 8:15 PM ET game Monday, which airs live on ABC/ESPN.

The Detroit Lions will face the San Francisco 49ers in week 17 of the NFL season on Monday Night Football at Levi's Stadium ...

San Francisco 49ers host the Detroit Lions on Monday Night Football to disrupt the Lions' quest for the NFC's No. 1 seed.

San Francisco 49ers TE George Kittle secured his 1,000-yard mark on the season with a 20-yard reception vs. the Lions.

The 49ers (6-9) have won so few they are vacating the NFC throne, having been eliminated last Sunday from playoff contention.

Guerendo took nine carries for 34 yards while bringing in all four targets for 65 yards in Monday's 40-34 loss to the Lions. Guerendo made a successful return from a one-game layoff due to foot and ...

The Week 17 edition of Monday Night Football may not mean much for either the San Francisco 49ers or Detroit Lions, but it means plenty for bettors and fantasy ...

SportsLine expert Jimmie Kaylor shares his Week 17 NFL DFS picks, stacks, sleepers, rankings, values, lineups and player pool ...

The 49ers (6-9) have won so few they are vacating the NFC throne, having been eliminated last Sunday from playoff contention.