Having clawed their way back to the top of the pile, leading Los Blancos on goal difference, Hansi Flick's side are determined to hold on to top spot.
Rovers were aiming to make history, while Manchester City’s worries continued over the fitness of top scorer Erling Haaland.
Spanish forward Samu Aghehowa gave Porto the lead against Roma after a 1-1 draw in Portugal last week, but two quick-fire goals from Dybala turned the tie in favour of the 2023 runners-up.