San Diego police were investigating a deadly shooting in broad daylight Wednesday in San Diego's Little Italy neighborhood.

Why do some people develop severe flu symptoms? A study points the finger at an unsung portion of the antibodies our immune systems generate to fend off invading pathogens.

Republicans had hoped to flip the seat after Levin turned it Democratic in 2018. The seat covers coastal north San Diego County and parts of southern Orange County.

Republicans maintained a slim House of Representatives majority in 2025, the Associated Press projected, thanks in part to California GOP incumbents holding onto their seats in close elections. That ...

Trump has threatened new, higher tariffs on two of California’s biggest trade partners, China and Mexico. The state’s workers and economy could feel the most impact.

An unarmed man who was attacked twice by a San Diego police dog and shot with multiple bean bag rounds in an incident last ...

Excessive force claim filed against City of San Diego, SDPD; Marcus Evans, 31, was struck 3 times by beanbag rounds and ...

SAN DIEGO (KUSI) — Another oarfish has made its way from the deep sea to the coast of San Diego County in Southern California ...

The company is planning to launch 20 Starlink satellites from its Falcon 9 rocket on Wednesday night from the California base ...

SAN DIEGO — California Assemblyman Matt Haney toured downtown San Diego on Wednesday, seeking solutions to revitalize urban centers across the state that continue to grapple with challenges in the ...

We’re making a lot of progress, but we're not yet solving the climate problem,” said David Victor, professor of public policy ...

“San Diego has a lot to share in terms of how to bring a downtown ... or in some cases get out of the way so California’s ...