Injuries are already biting the San Francisco 49ers after two of their top players were dinged up last week in the season-opening win over the Seattle Seahawks, yet the Niners are still 4.5-point favorites in Week 2.

Detroit Lions quarterback Jared Goff and San Francisco 49ers linebacker Fred Warner have made his appearance on the NFL Top 100 at No. 15 and 16, respectively.

After months of buildup, the 2025 NFL season kicked off in a major way during Week 1. With the dust now settled, here’s a look at the top

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See the latest NFL MVP odds with expert insights, top contenders and sportsbook offers. Make the most of the season with updated odds to win NFL MVP.

As the NFL continues to unveil its Top 100 Players of 2025, Goff has popped up on the list all the way up at No. 15. Goff jumps up a whopping 33 spots from his No. 48 ranking in 2024. Goff led the Lions to a 15-2 record and the No. 1 seed in last season's playoffs, throwing for 4,629 yards, 37 touchdowns and went to his 4th Pro Bowl.

It was a dominating Week 1 win for the Indianapolis Colts over the Miami Dolphins. However, in ESPN's Week 2 power rankings, the Colts jumped only a few spots. Now, I didn't expect the Colts to be a top 15 team,