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GPR30 in brain microvasculature responds to bicarbonate, and its deficiency protects against ischemia-reperfusion injury, reducing neurological deficits and blood-brain barrier disruption. These ...
Discovery of bicarbonate-sensing receptor offers therapeutic insights into ischemic stroke treatment
Researchers have identified this receptor in brain mural cells that regulates reperfusion injury. Optimal pH homeostasis for cellular function is maintained by the acid-base balance through multiple ...
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