Brissett completed 47 passes in Arizona's 41-22 loss to the San Francisco 49ers at State Farm Stadium to etch his name in the NFL record books for most completions in a regular-season game. He produced a career-high 452 passing yards in the process.

Shedeur Sanders took the first regular-season snaps of his NFL career on Sunday when Dillon Gabriel was checked for a head injury.

The Arizona Cardinals quarterback, who is filling in for the injured Kyler Murray, completed 47 of his 57 pass attempts, setting a new record for completions in a single game. Drew Bledsoe had 45 completions in 1994, and Jared Goff had the same mark in 2019.

Hopefully you're locked in and ready for some NFL football this Sunday, because we might have a pair of playoff previews in store!

Welcome to the NFL, Shedeur Sanders. A regular-season debut that had been long-awaited finally happened on Nov. 16, as the Cleveland Browns' rookie got into a game. It came at the expense of fellow rookie Dillon Gabriel, who was knocked out of the Week 11 contest to be evaluated for a concussion.

Cleveland Browns quarterback Shedeur Sanders has made his NFL debut. The highly publicized quarterback entered Sunday against the Baltimore Ravens with 12:43 remaining in the third quarter after the team announced that Dillon Gabriel was being evaluated for a concussion.

It appears the Pittsburgh Steelers could be without Aaron Rodgers for some time after the star quarterback exited Sunday's 34-12 win over the Cincinnati Bengals with a wrist injury.

NFL fans are in agreement on Drew Brees' broadcasting debut on Sunday. The legendary NFL quarterback is on the call of the New York Giants vs. Green Bay Packers game on Sunday. Brees, 46, made 13 Pro Bowls and won Super Bowl XLIV MVP with the Saints during his 20-year NFL career.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.