Individuals with HIV who were resistant to all four antiretroviral drug classes experienced higher mortality than those who were not resistant, a difference primarily due to lower CD4 cell counts.

First-in-class drugs can be highly innovative because of their novel mechanisms of action, but they also carry uncertainty in the absence of clinical experience. To understand how such drugs advance ...

The choice of which therapeutic alternatives to compare drugs against will be foundational in Medicare’s drug price negotiation, now and in future years. We believe a broad approach to the selection ...

Researchers looked specifically at head-to-head randomized clinical trials of next-in-class cancer drugs against existing agents in the same class. Less than one-quarter of next-in-class cancer drugs ...

Isabelle Sapherson-Moralee, known as Izzy, suffered chronic pain and was just 5st 9lb (39kg) when she died in April 2025, ...

Add Yahoo as a preferred source to see more of our stories on Google. Nitazenes, like this powder sample, are a class of synthetic opioids more potent than morphine and fentanyl. Joe Lamberti/The ...

Credit: Getty Images In an unexpected finding, phosphodiesterase inhibitors and sympathomimetics with α- and β-effect were strongly associated with higher AKI risk in this analysis. High AKI risk was ...

There is no biological measure for wakefulness. In a narcolepsy clinical trial, a patient lies down in a dark lab while clinicians count the minutes until sleep comes. The average time in four tests ...

A newly discovered antibiotic can sidestep the defenses of a dangerous, drug-resistant bacterial species. The drug targets CRAB, or carbapenem-resistant Acinetobacter baumannii, which shows resistance ...