Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

The San Francisco 49ers are already without Fred Warner, and they may have lost another linebacker early against the Arizona Cardinals on Sunday.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

The Arizona Cardinals and San Francisco 49ers revealed their final inactives report for Week 11 - who's in, who's out?

Signs pointed toward CB Deommodore Lenoir not being able to play for the San Francisco 49ers on Sunday, but their inactives told a different story.

The Cardinals quarterback completed 47 passes against the San Francisco 49ers — a new NFL record. Brissett went 47-of-57 for 452 yards, two touchdowns and two interceptions. The 49ers, though, were too much for the Cardinals as they fell, 41-22 in Week 11. Arizona has now lost five of its last six games.

» Not only did the Niners’ tight end catch a touchdown of his own, but he was instrumental on the 49ers’ third touchdown of the game, where he ran a legal pick to free up Christian McCaffrey for an untouched score.

Wide receiver Skyy Moore returned the opening kickoff 98 yards and running back Christian McCaffrey got the final yard the Niners needed for a touchdown one play later. That made it 7-0 with 16 seconds off the clock in Arizona.