San Francisco 49ers kicker Eddy Piñeiro and linebacker Tatum Bethune have been standouts as in-season substitutes, but both will miss several games after injuries sustained against the Cardinals.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

A former NFL star accused the Arizona Cardinals of point-shaving against the 49ers on Sunday after San Francisco cruised to a 41-22 victory in the NFC West showdown.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

San Francisco 49ers head coach Kyle Shanahan said he had big comebacks in mind when he kept Christian McCaffrey on the field with his team leading by 19 late in Sunday's game.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

Charlotte native Owen McCown led the Roadrunners' offense with 306 yards, three total touchdowns, and an interception in his homecoming as head coach Jeff Traylor and his team improved to 5-5, needing one more win to achieve bowl eligibility.

San Francisco 49ers tight end George Kittle has been thoroughly impressed by what he's seen from defensive lineman Alfred Collins so far this year.

SANTA CLARA, Calif. (AP) — Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly two years. While Purdy looked sharp in the 41-22 victory over the Arizona Cardinals on Sunday, the reasons behind the big scoring output have to do with a lot more than just the change at quarterback.