America's relationship with its biggest Middle East adversary has changed dramatically over the decades. Investors are weighing a NYT report that Iran has indirectly approached the US to discuss terms for ending the conflict. Markets are reacting to a lack of clarity and shifting expectations in the first days of a chaotic conflict.

Israel decided days after Hamas’ Oct. 7 attack to target Iran’s Supreme Leader Ali Khamenei, while detailed planning came later, USA TODAY learned.

In the latest mark of how much the conversation among Democratic leaders around Israel is shifting, California Gov. Gavin Newsom on Tuesday night blamed Prime Minister Benjamin Netanyahu for pushing the US into war with Iran and said the United States must reconsider future military aid to its longtime ally.

Secretary of War Pete Hegseth declared Wednesday that Iran “cannot outlast” the U.S. in a conflict as its military has been decimated as a result of Operation Epic Fury, which is now in its fifth day.

President Donald Trump said the objective is to defend the American people by eliminating imminent threats from the Iranian regime. He said Iran has continued to develop nuclear weapons.

March 4 (Reuters) - The U.S. military has joined Israel and attacked more than 1,000 targets in Iran and killed many of its top officials, including Supreme Leader Ayatollah Ali Khamenei. On Wednesday, a U.S. submarine sunk an Iranian navy vessel near Sri Lanka.

President Donald Trump submitted to Congress a war powers notification regarding military action taken on Feb. 28 against the government of Iran.

Iranian-Americans in Wisconsin are applauding the United States and Israel for their military intervention in Iran and are celebrating the death of Ali Khamenei.